ABSTRACT
The aim of this document is to provide physicians treating patients with a history of COVID-19 pneumonia with recommendations on proper diagnostics and management of respiratory sequelae associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The expert panel provides 32 recommendations with respect to the treatment of lung consequences (including antibiotic therapy, corticosteroid therapy, and antithrombotic prophylaxis and treatment), pulmonary rehabilitation, lung transplantation, patient monitoring, and ambulatory settings. The management of patients with respiratory comorbidities (asthma, chronic obstructive pulmonary disease, lung cancer, and interstitial lung disease) and the medications used for treatment of these conditions, such as corticosteroids and antifibrotic drugs, is discussed. Presented recommendations are based on the most recent reports and aimed at providing patients post-COVID-19 respiratory sequelae with optimal standards of care.
ABSTRACT
Biological therapy is the breakthrough in the management of spectrum of various diseases. It also concerns asthma therapy. The data regarding the role of biologics in the treatment strategy of severe asthma are presented. The overview on how mediators of type 2 inflammation drives the pathology of the disease is given. It justifies the biological treatment options approved. The development of treatment strategy targeting non-type 2 inflammation is also highlighted. The data regarding the risk and safety of biologics are discussed. Document includes the featured rules of the classification of patients with severe asthma to this reliable and efficient therapy. The outlook how to perceive the safety of biologics in the time of COVID-19 epidemic is also given.